A simple, precise, specific, accurate and validated RP-HPLC method has been developed to determine Aspirin (ASP) and Rosuvastatin calcium (RSV) in capsule dosage form. Chromatographic separation achieved on ACE, C18 column (150 mm x 4.6mm i.d, 5µ), and Acetonitrile : 25mM phosphate buffer (pH 3.0) in the ratio of 40:60 (v/v) as the mobile phase, at a flow rate of 1 ml/min and injection volume 10µl. Detection was carried out at 260 nm. The retention times for ASP and RSV was found to be 3.3±0.16 and 7.8±0.27 min respectively. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness are studied as reported in the ICH guidelines. The method was linear in the concentration range of 15-120 μg/ml for ASP and 2-16 μg/ml for RSV with correlation coefficient of 0.999 and 0.999 respectively. The recoveries obtained for ASP and RSV were 99.27-101.85% and 98.86-102% respectively. The developed method was found to be accurate, precise, specific and sensitive for simultaneous estimation of ASP and RSV.
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